Objective To investigate the applying values of spiral CT angiography in the abnormal blood vessels. Methods Selected 172 patients of coronary heart disease from July 2008 to September2014 in our hospital as the observation group, choose 172 notcoronary heart disease patients at the same period in our hospital for coronary angiography as the control group, both groups were given the color ultrasound analysis and spiral CT angiography judgment. Results The IMT value of the observation group were significantly higher, while the SPV, MSV and EDV values were significantly lower than the control group (P＜0.05). The observation group were more showed calcified and ulceration plaques, while the control group were showed more normal, lipid and fibrous plaque that compared difference were statistically significantly (P＜0.05). The total area of the blood vessel stenosis of the observation group were significantly higher (P＜0.05). Conclusion The spiral CT angiography combined with ultrasound can effectively determine abnormal blood flow, plaques and stenosis situation in patients with coronary heart disease which is conducive to the identification and diagnosis of disease.