Objective To explore CT diagnosis and clinical characteristics of children with epilepsy induced by tuberous sclerosis. Methods The clinical data and CT findings of 30 children with TSC complicated with epilepsy were retrospectively analyzed and summarized. Results CT examination showed that there was nodular high density shadow under periosteum of external ventricle wall of the lateral ventricle, variable in size with homogeneous density. There were 22 cases with nodular high density shadow in cerebral ventricle, 4 cases with nodular high density shadow in cerebral cortex of hemicerebrum and 2 cases with nodular high density shadow in white matter. Among the 30 cases of patients, 17 cases were younger than 1 years old, 6 cases 1-3 years old, 5 cases 4-6 years old, 2 case over 6 years old; 20 cases were single seizure, 7 cases 2 kinds of seizures at the same time and 3 cases 3 kinds of seizures at the same time; There were 25 cases complicated with skin lesions, 18 cases with mental retardation and 27 cases with abnormal EEG. Conclusion CT combined with clinical characteristics and EEG of children with epilepsy induced by tuberous sclerosis can be used as an important imaging method for the diagnosis of epilepsy induced by nodular sclerosis