Objective To investigate the cinical value value of diffusion-weighted magnetic resonance imaging (DWI) in predicting the radiosensitivity of cervical cancer. Methods Twenty-five women with cervical cancer received radiotherapy were included, DWI was carried out prior to radiation, and repeated after 20GY and after the readiation using MRI scanner. The apparent diffusion coefficient (ADC) was calculated, compared and correlated with final tumour retraction. Results The ADC values of prior to radiation, 20GY and t after the readiation was (0.93±0.14)×10-3, (1.25±0.17)×10-3and (1.55±0.13)×10-3mm2 /s, it showed significant difference each other (P<0.01). The change of ADC between prior to radiation and 20GY therapy was (0.33±0.16)×10-3 mm2 /s, final tumour retraction was (0.86±0.11)×10-3mm2 /s. No correlation was found between ADC values and tumour retraction (P>0.05), while the changes in ADC showed a significant correlation with tumour retraction (r=0.423,P=0.035). Conclusion The ADC values of cervical cancer increased after radiotherapy, the early change of ADC value showed a correlation with final tumour retraction, Which has the potential to provide a surrogate biomarker of radiosensitivity in cervical cancers.