Objective To explore the correlation between gastric cancer multi-slice spiral CT perfusion imaging and perfusion and tumor factor. Methods 32 cases of gastric cancer patients random selected from Department of oncology in our hospital from 2010 January to 2012 September as the observation group, 40 cases healthy subjects randomly chosen in the physical examination center as control group, the two groups of subjects were using CT perfusion imaging, compared blood flow perfusion software into the packet processing after the CT perfusion (Perfusion)(blood volume or per unit time per 100gin renal tissue)、blood volume (100g in renal tissue of blood within the capacity of (BV))、 peak enhancement (PEI), time to peak (TTP),mean transit time (MTT), permeability surface (PS) differences and related tumor factor levels of two groups, and analyzed the correlation between CT perfusion parameters and tumor factor by using Pearson analysis method. Results The observation group and the control group Perfusion, PEI, TTP, PS with significant difference (p<0.05) between the two groups; BV, MTT difference was not statistically significant (p>0.05); observation group tumor factor CEA, AFP, CA199, CA72-4 levels were significantly higher than those in the control group and the difference was statistically significant (p<0.05); Perfusion, PEI, PS and tumor factor CEA, AFP,CA199, CA72-4 there is a significant positive correlation between TTP and tumor factor, CEA, AFP, CA199, CA72-4 showed a significant negative correlation between. Conclusion Multi-slice spiral CT perfusion imaging in detection of gastric cancer can effectively analyze tumor factor level, there is a good correlation between them.