Objective To investigate the CT features and compared with pathology of Castleman disease (CD). Methods CT findings and pathology data of 11 cases with CD proved by pathology were analyzed retrospectively. Results ① There were 7 cases in the retroperitoneal, 3 cases in the mesenteric root, 1 case located in the iliac blood vessels pedestrian area. 10 cases were localized and pathological types were hyaline vascular type, 1 case was diffuse and plasma cell type. ② CT scan showed that 10 cases were equal density, 1 case was slightly low density, all were uniform density and without cystic necrosis, 2 cases l were seen branch calcification at centra. Contrast-enhanced CT: 7 cases showed heterogeneous significantly enhanced 3 cases homogeneous moderate enhancement and 1 case mild homogeneous enhancement at arterial phase, five cases were seen significantly enhanced tumor blood vessels around the edge or shadow; 8 cases continued homogeneous enhancement at intravenous, 3 cases center fill strengthen; all showed slightly more uniform density at delay period. Conclusion CT performance of CD of the abdomen and pelvis was closely related to the histological type, especially hyaline vascular type CD performance had a certain characteristic, CT examination had great value for the diagnosis of CD.