Objective To discuss the diagnosis value of CT and MRI in spinal tuberculosis. Materials and Methods Retrospective analysis of 45 cases (22 cases of CT,23 cases of MRI(15 cases of both), 2 cases of enhancement scan)confirmed by the surgical operation pathology, needle biopsy and antituberculosis therapy imaging of CT and MRI material of spine tuberculosis. Results 45 cases of spinal tuberculosis, cervical vertebra lesion in 2 case, thoracic vertebra lesion in 11 cases, thoracolumbar spine lesion in 16, lumbar vertebra lesion in 18 cases, lumbosacral vertebrae in 5 cases, sacral vertebrae in 3 cases were found. The CT could show the bone destruction, the bone increase osteoslerosis, sequestrum formation, swelling paraspinal soft tissue and calcification, etc. MRI could show bone marrow edema, paravertebral abscess formation, changes of intervertebral disc, spinal canal and the dural sac. Conclusion CT and MRI in the diagnosis of spinal tuberculosis has obvious value. CT has an advantage over showing sequestrum and calcification. MRI has an advantage over showing the early tuberculous, confirm the range of lesions, epidural and spinal cord invasion, etc. Synthesizing characteristics of the both will help to diagnosis, differential diagnosis of spinal tuberculosis.