Head and Neck Imaging
Analyses of Brain in Children after Chemotherapy with Acute Lymphoblastic Leukemia by using Proton Magnetic Resonance Spectroscopy*
Author：CAO Wei-guo, GAN Yun-gen, ZHAO Cai-lei et al
affiliation：Department of Radiology, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong Province, China
PDFAbstract
Objective To investigate the value of proton magnetic resonance spectroscopy( 1 H MRS) in the pediatric patients after chemotherapy with acute lymphoblastic leukemia (ALL). Methods 20 pediatric patients(2-10 years) with ALL and 20 pediatric volunteers(2-10 years) were examined with 1H MRS, the relationship between MRS values[N-acetylasparate(NAA), Choline(Cho), Creatine(Cr), Lactate(Lac), NAA/Cr, NAA/Cho, Cho/Cr] and intelligence quotient (IQ) by WISC-IV were analyzed. Results NAA/Cho and NAA/Cr in complete remission(CR) ALL patients were diminished, as compared with normal volunteers, Meantime, MRS values were significantly correlated with IQ in CR patients with ALL. Conclusion MRS has an important value to assess the intelligence of CR patients with ALL. [Key words] Acute Lymphoblastic Leukemia; Proton Magnetic Resonance Spectroscopy(1 H MRS); Children; Intelligence Quotient
【Keyword】Acute Lymphoblastic Leukemia; Proton Magnetic Resonance Spectroscopy(1 H MRS); Children; Intelligence Quotient
【Chart number】R445.2；R725.5
【Document Identification Number】A
【DOI】 10.3969/j.issn.1672- 5131.2016.01.008
Chinese journal of CT and MRI
th14Volume， th 1 Issue
2016Year01Month
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