Objective To investigate the effect of the series of hemoperfusion hemodialysis treatment on parathyroid hormone. Methods From January 2015 to January 2016, 90 cases of uremic inpatients were selected as research objects. According to admission, patients were divided into observation group and control group with 45 cases of each group randomly. Patients in observation group were underwent hemoperfusion in series hemodialysis treatment, while only hemodialysis were underwent in control group. The effect of dialysis and the change of parathyroid hormone before and after dialysis were compared among groups. Results The observed group was better clinical improvement than control group after treatment, and the difference was statistically significant (P<0.05). Before and after treatment in two groups Ca2 + concentration was no significant change in serum PTH, P3 + two indicators were significantly higher in the control group of patients on dialysis, serum PTH, P3 + two indicators decreased significantly after the observation of patients on dialysis, the difference statistically significance (P<0.05). Conclusion Hemoperfusion series hemodialysis in patients with uremia can significantly increase the effect of dialysis, reduce parathyroid hormone levels, relieve side effects such as skin itch and ostalgia caused by dialysis, is worthy for wider application.