Objective To observe the clinical effect of high-flux hemodialysis combined with hemodiafiltration therapy in hemodialysis patients with uremia resistant hypertension. Methods 30 patients of hemodialysis uremic refractory hypertension (using three or more antihypertensive drugs lower blood pressure, blood pressure control is not achieved) were randomly divided into two groups. 1. 15 cases of series group (HD + HDF) , use HD twice a week united HDF once a week. 2. 15 cases of control group (HD group), use simple hemodialysis and HD three times a week. Thetreatment was last forthree months with HD4h and HDF4h each time. Results Both groups of patient had been treated effectively to some extent, but the total effective rate (93.33% (14/15) )of patients in observational group was clearly higher than that of the ones in control group (60% (9/15) ). The score (8.52±1.46) of satisfaction degree of patients in observational group was clearly higher than that of the ones in control group (4.02±0.32). All the differences were significant (P<0.05), having a statistical significance. Conclusion The use of high-flux hemodialysis combined with hemodiafiltration therapy can achieve safer and more effective treatment, higher satisfaction of patients with uremia, which should be widely applied in clinical practice.