Head and Neck Imaging
Expressions of Bcl2 and Bcl6 in Ulcerative Colitis*
Author：WU Hui-hua, HE Xing-zhen, LI Xi.
affiliation：Department of Gastroenterology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
PDFAbstract
Objective To investigate the significance of the expressions of Bcl2 and Bcl6 in patients with ulcerative colitis (UC). Methods The immunohistochemical method was applied to detect the expressions of Bcl2 and Bcl6 in colorectal tissues of 25 patients in UC group and 20 healthy controls. Further,the patients and healthy controls were detected in Shenzhen Hospital of Peking University from March 2013 to November 2014. Results The expression of Bcl2 in UC group(0.15±0.08)was lower than that in normal control group(0.22±0.11), but the difference had no statistical significance (P=0.054). And the expression of Bcl6 in UC group(0.35±0.12) was lower than that in control group(0.50±0.13), the difference had statistical significance(P=0.001). Conclusion The lower expression of Bcl6 in colorectal tissues of UC may play an important role in the pathogenesis of UC, which provides patients with UC with a new direction of clinical diagnosis and therapy.
【Keyword】Bcl2; Bcl6; Ulcerative Colitis
【Chart number】R446；R574.1
【Document Identification Number】A
【DOI】10.3969/j.issn.1009-3257.2018.02.002
Journal of Rare Diseases
th25Volume， th 2 Issue
2019Year11Month
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