Objective To observe the effect of comfort nursing intervention on symptom improvement and treatment compliance in patients with reflux esophagitis(RE). Methods From Feb. 2015 to Jan. 2017, 200 RE patients hospitalized in our hospital were taken as the research objects according to the related inclusion and exclusion criteria, and they were divided into control group (100 cases) and observation group (100 cases). The control group was given conventional nursing, and the observation group was given comfort nursing intervention. The improvement of clinical symptoms and treatment compliance in the two groups was compared. Results Before intervention, there were no significant differences in scores of reflux and vomiting symptoms, medication compliance and nursing compliance between the two groups (P>0.05), after intervention, the symptoms and treatment compliance in the two groups were significantly improved, and the improvement of reflux and vomiting symptoms scores, medication compliance and nursing compliance in the observation group was significantly higher than that in the control group, and the difference was statistically significant (P<0.05). Conclusion Comfort nursing can strengthen the compliance of medication and nursing behaviors, and improve the clinical symptoms more effectively in RE patients.