Objective To analyze the related risk factors of premature rupture of membrane and its impact in the pregnancy outcome and provide the objective theory basis in the early diagnosis of preterm premature rupture of membrane and take the effective intervention measures. Methods 100 pregnant women of premature rupture of membrane delivered from January 2014 to January 2016 in our hospital were selected. The gestational weeks were 28w-37w. The subjects were divided into Group A, Group B and Group C according to the different gestational weeks. The correlation factors of preterm premature rupture of membrane and the impact of rupture time in the pregnancy outcome was analyzed. Results According to the related factors for preterm premature rupture of membrane, the rate of the reproductive tract infection (colpitis, pelvic inflammatory disease), history of induced abortion and abnormal fetal position (breech delivery, cephalopelvic disproportion) accounted for 30%, 22% and 14%. The rate of Cesarean section and natural delivery for three groups was significantly different (P<0.05), as the gestational weeks were extended, the rate of natural delivery was higher and the rate of Cesarean section was lower. For the different rupture time, the rate of intraamniotic infection and puerperal morbidity was signficantly different (P<0.05), as the rutpure time exceeded 24 hours, the rate of intraamniotic infection and puerperal morbidity was greatly increased. Conclusion The major factors of premature rupture of membrane include reproductive tract infection and history of induced abortion. It needs to focus on the pre-pregnancy checks and antenatal care and choose the suitable delivery mode according to the patient’s conditions. Based on the shorter gestational weeks, the pregnancy outcome is worsened with the longer rupture time. The proper intervention can improve the clinical symptom.