目的 研究14种长链非编码RNA（Long non-coding RNA, lncRNA）在成骨不全骨组织中的表达。方法 采用先天性 骻关节脱位患者骨组织作为对照，应用RT-qPCR分析成骨不全骨组织中14种lncRNA(ATB、EBIC、HEIH、hLACR1、 HOTAIR、PVT1、LET、Loc285194、SRHC、LSINCTS 、Nbla10727、Nbla12061、PRNCR1与UC.388)的表达，使用 REST-2009软件进行数据统计分析。结果 与对照组相比，14种lncRNA中仅PRNCR1表达下调并具有显著性差异； ATB、EBIC、HOTAIR、PVT1、LET、Loc285194、SRHC等7种lncRNA表达差异均小于2倍，LSINCTS表达下调，HEIH、 hLACR1、Nbla10727、Nbla12061与UC.388等5种lncRNA表达上调，但均无统计学意义。结论 PRNCR1在成骨不全骨组 织中低表达，其在成骨不全疾病的功能尚有待于进一步研究。

Objective To explore the differential expression of 14 kinds of long non?--coding RNAs in bone tissues derived from osteogenesis imperfecta patients. Methods RT-qPCR was performed to detect the expression level of 14 Kinds of lncRNAs including ATB, EBIC, HEIH, hLACR1, HOTAIR, PVT1, LET, Loc285194, SRHC, LSINCTS, Nbla10727, Nbla12061, PRNCR1 and UC.388 in bone tissues derive from osteogenesis imperfect (OI) patients who received corrective surgery. Bone tissues from developmental dysplasia of the hip (DDH) were used as control. REST-2009 was performed to analyze the results. Results The expression of PRNCR1 was significantly down-regulated in OI bone tissues. There’s no differential expression was observed in other thirteen lncRNAs, though the expression of HEIH, hLACR1, Nbla10727, Nbla12061 and UC.388 were up-regulated and LSINCTS was down-regulated. The expression of ATB,EBIC, HOTAIR, PVT1, LET, Loc285194 and SRHC was less than 2-fold of DDH control. Conclusions Low expression of PRNCR1 was observed in bone tissue from OI patients. The functions of PRNCR1 in OI need further study.