目的 探讨Pipelle子宫内膜采集器在子宫内膜病变检查中患者耐受性及诊断价值。方法 选取2014年6月至2016年3 月就诊于北京大学深圳医院妇科门诊行子宫组织活检的女性，分别采用Pipelle子宫内膜采集器与B超引导下分段诊 刮术收集子宫内膜组织，记录患者主观疼痛指数及病理诊断结果。以B超引导下分段诊刮术为参照，分析Pipelle子 宫内膜采集器对病人的耐受性及诊断准确性。结果 共92例女性入组，Pipelle子宫内膜采集器采集取材满意度为 83.7%（77/92），子宫内膜采集器与分段诊刮病理结果总符合率为84.4%（65/77），对诊断正常子宫内膜、子宫内 膜息肉、子宫内膜增生、子宫内膜非典型增生及子宫内膜癌的敏感度及特异度分别为93.6%和63.3%、40%和98.6%、 68.8%和100%、88.9%和100%。结论 Pipelle子宫内膜采集器具有与B超引导下分段诊刮在诊断子宫内膜病变具有同 样的临床诊断价值，具有更好的耐受性，但对于局灶性病变的敏感性不及B超引导下分段诊刮术。

Objective To evaluate the diagnostic significance of Pipelle for endometrial pathology. Methods The patients were recruited to our study from gynecologic clinics for endometrial sampling, from June, 2014 to March 2015. We collected the endometrial tissue by Pipelle and D&C under the instruction of sonography, took the record of pain index and pathologic diagnosis. We analyzed the tolerance and the diagnostic accuracy of Pipelle compared with D&C. Results 92patients were included to our study. The satisfactory sampling rate was83.7%. The coincidence rate of Pipelle was 84.4%.Sensitivity and specificity for normal endometrium, endometrial polyps, endometrial hyperplasia, endometrial atypia and cancer were 93.6% and 63.3%, 40%and 98.6%, 68.8%and 100, 88.9%and 100%. Conclusions Pipelle had the same diagnostic significance for endometrial pathology, and the better tolerance for patients, but limitation for focal neoplasia.