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·系统性疾病·

艾滋病相关淋巴瘤的影像学表现

作者:罗益贤 陆普选 乐晓华 王 辉

所属单位:深圳市第三人民医院 (广东 深圳 518112)

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摘要

目的 探讨艾滋病相关淋巴瘤的特征性影像学表现。方法 回顾分析7例经活检病理确诊的艾滋病合并淋巴瘤患者的X 线、CT及MRI资料,并复习相关文献,从而总结艾滋病相关淋巴瘤的影像学表现特点。结果 2例主要表现为颈部淋 巴结肿大,2例为腋窝淋巴结肿大,1例为咽扁桃体肿大,1例为回肠末段巨大肿块,1例为多发骨质破坏。其中6例 患者出现淋巴结肿大,6例出现肺部病变,3例肝脏内出现低密度影,2例脑实质内异常信号,1例硬脑膜增厚并头皮 肿胀,1例胰腺肿大、主胰管扩张;1例腰椎多发骨质破坏并椎体压缩;1例脊髓膨大并信号不均;1例胸部多发骨质 破坏。结论 艾滋病相关淋巴瘤广泛累及淋巴结及结外淋巴组织,表现为巨大淋巴结肿大同时合并其他组织器官受 累,影像学表现有一定的特点,但缺乏特异性,诊断需结合临床。

Objective To investigate the specific imaging features of AIDS-related lymphoma. Methods X-ray, CT and MRI findings of 7 cases with Pathological biopsy proved AIDS-related lymphoma were retrospectively analyzed. And the related literature was reviewed to summarize the imaging features of AIDS-related lymphoma. Results Among the 7 cases, the main manifestations were enlargement of cervical lymph nodes (n=2), axillary lymph nodes(n=2) , tonsil enlargement (n=1), huge mass in terminal ileum (n=1), and multiple bone destruction (n=1). All of them, enlargement of lymph nodes were found in 6 cases, chest diseases were found in 6 cases, low density masses of liver were found in 3 cases, abnormal signals of brain were found in 2 cases ,dura thickening and scalp swelling were found in 1 case, pancreatic duct dilatation and pancreatic enlargement were found in 1 case, multiple vertebral body destruction and compression were found in 1 case, uneven signal was found in the swelling spinal cord in 1 case, multiple chest bone destruction were found in 1 case. Conclusion The imaging features of AIDS-related lymphoma which showed enlargement lymph nodes associated with other organ involvement is lack of specificity, and still need to be combined with clinical symptoms when we diagnosed.

【关键词】获得性免疫缺陷综合征;淋巴瘤;体层摄影术;X线计算机;磁共振成像

【中图分类号】R73;R5

【文献标识码】A

【DOI】10.3969/j.issn.1009-3257.2015.02.017

前言

艾 滋 病 ( a c q u i r e d i m m u n o d e f i c i e n c y syndrome, AIDS)是由于人免疫缺陷病毒(human immunodeficiency virus, HIV)感染而导致的致命性 慢性传染病。该病毒主要侵犯人体免疫系统,破坏辅 助性T淋巴细胞(CD4+T淋巴细胞),使机体免疫功能受 损,最后并发各种严重的机会感染和恶性肿瘤。在艾 滋病感染患者中,淋巴瘤发病率约5%~20%[1],仅次 于卡波西肉瘤。本文回顾性分析7例艾滋病相关淋巴 瘤(acquired immune deficiency syndrome-relatedlymphoma, ARL)的影像学表现,同时复习相关文献, 旨在增加对本病的认识,提高诊断水平。