目的 探讨健康管理防治高同型半胱氨酸血症的价值。方法 将健康体检中MTHFR C677T基因多态性伴HHcy、血脂异 常增高者作为研究对象，随机分成对照组和观察组。两组在规范叶酸、维生素B6强化治疗的基础上，又对观察组实 施个性化健康促进干预措施。结果 对照组连续6个月药品强化治疗后，Hcy、血脂水平未明显下降，差异无统计学 意义(P>0.05)。连续12个月药品强化治疗后，Hcy及血脂水平明显下降，差异有统计学意义(P<0.001,P<0.05)。观 察组在个性化健康促进干预6个月、12个月后，Hcy及血脂水平显著降低，差异有统计学意义(P<0.001，P<0.001)。 结论 健康管理可显著降低MTHFR C677T基因多态性伴HHcy、血脂异常目标人群Hcy、血脂水平，提高服药依从性， 这将有助于控制高危因素，预防脑血管疾病的发生。

Objective To explore the value of health management in prevention and treatment of hyperhomocysteinemia. Methods The research object was people with MTHFR C677T gene polymorphism, HHcy and abnormal blood lipid had been screened in physical examination who were divided into a control group and a observation group. Two groups took specification of folic acid, vitamin B6 treatment, observation group to implement personalized health promotion interventions. Results Hcy and lipid of the control group was not significantly lower in 6 months after drug treatment. There was no statistically significant difference (P>0.05). Hcy and lipid of the control group was significantly lower in 12 months after drug treatment.There was statistically significant difference (P<0.001,P<0.05). Hcy and lipid of the observation group was significantly lower in personalized health promotion intervention 6 months and 12 months later.There was statistically significant difference (P<0.001,P<0.001). Conclusion Health management can reduce the target population Hcy and lipid level, increase medication compliance, this will help to control the risk factors, prevent the happening of the cerebrovascular disease.