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不同严重程度急性 胰腺炎患者炎症状 态及MSCT表现分析

作者:朱秀英1 吴清武2 陈希妍1 吴 畏1 李广鹏1 张江波1

所属单位:1.新乡医学院第一附属医院急诊科 (河南 新乡 453100) 2.新乡医学院第一附属医院放射科 (河南 新乡 453100)

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摘要

目的 探讨不同严重程度急性 胰腺炎(AP)患者炎症状态和多层螺旋 CT(MSCT)表现。方法 回顾性分析2016年5 月-2018年5月我院收治的68例AP患者的临 床资料。根据AP严重程度分级将患者分为 轻症急性胰腺炎组(MAP组,41例)和重症 急性胰腺炎组(SAP组,27例),另选择同 时期健康体检者20例作为对照组。3组受 试者均接受MSCT检查,记录CT分级情况, 比较3组受试者血清C反应蛋白(CRP)、血 清淀粉酶(AMY)和尿淀粉酶(UAMY)水平差 异。结果 MAP组、SAP组血清CRP水平均高 于对照组,且SAP组﹥MAP组(P﹤0.05);MAP 组、SAP组AMY、UAMY水平均高于对照组(P ﹤0.05),组间比较差异无统计学意义(P﹥ 0.05);Balthazar CT表现A级、B级、C 级、D级、E级各8、15、20、20、5例。结 论 SAP患者炎症状态严重于MAP,其相应 CT表现也存在明显差异,可作为病情评估 的重要依据。

Objective To explore the inflammatory status and multi-slice spiral CT (MSCT) performance in patients with acute pancreatitis (AP) of different severity. Methods The clinical data of 68 patients with AP admitted to our hospital from May 2016 to May 2018 were analyzed retrospectively. According to the severity of AP, the patients were divided into mild acute pancreatitis group (MAP group, 41 cases) and severe acute pancreatitis group (SAP group, 27 cases). And another 20 healthy examiners at the same time were selected as control group. All the three groups were given MSCT examination, and the CT classification was recorded. The levels of serum C-reactive protein (CRP), serum amylase (AMY) and urinary amylase (UAMY) were compared among the three groups. Results The serum CRP level in MAP group and SAP group was higher than that in control group, and the level in SAP group was higher than that in MAP group (P<0.05). The levels of AMY and UAMY in MAP group and SAP group were higher than those in control group (P<0.05), and there was no statistically differences (P>0.05). The cases of grades A, B, C, D and E of Balthazar CT score were 8, 15, 20, 20 and 5. Conclusion The inflammatory status of SAP patients is significantly worse than that of MAP patients. There are also significant differences in CT performance, which can be used as important basis for disease assessment.

【关键词】急性胰腺炎;MSCT;C反应蛋 白;淀粉酶

【中图分类号】R657

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2019.06.029

前言

急性胰腺炎(AP)是由于胰酶被激活导致胰腺组织自身消化、水 肿、坏死的一种炎症疾病,是临床常见急腹症之一,病情发展迅速, 诊治不及时可能致使病情恶化、甚至造成器官衰竭,危害患者生命健 康。轻症急性胰腺炎(MAP)占比较高,通常在发病后2周内恢复,预后 较好,重症急性胰腺炎(SAP)通常伴有严重并发症,预后不佳,若伴随 感染则病死率增加,因此早期诊断并评估病情严重程度是及时治疗的 前提、对改善预后有积极意义。多层螺旋CT(MSCT)可清晰显示胰腺组 织结构、形态和炎症程度,是临床诊断AP的重要影像学检查方法,且 CT分级对AP病情评估的准确性已得到临床认可[1]。本研究旨在探讨不同 程度AP患者的炎症状态并分析其在MSCT上的表现,为临床诊断和评估 提供科学依据,现报道如下。