目的 观察3.0T MRI在诊断三 阴性乳腺癌(Triple Negative Breast Cancer)中的应用情况，为术前的临床诊 断提供参考。方法 选取2015年3月-2018 年3月我院收治的女性乳腺癌患者110例作 回顾性分析，根据病理检查结果分为三阴 性乳腺癌组(TNBC组)42例，非三阴性乳腺 癌组(非TNBC组)68例。通过3.0T 磁共振 弥散加权成像(MRI-DWI)进行乳腺扫描， 比较两组患者病理学特征(肿瘤数量、大 小、形状及边界光滑与否、周遭血管数量 等)，观察两组MRI动态强化特征的差异； 对比两组时间-信号强度(TIC)曲线类型、 T2WI信号强度和ADC值。结果 与非TNBC组 比较，TNBC组的肿瘤多为圆形，且边缘光 滑，周遭血管明显增加，差异均有统计学 意义(P<0.05)；TNBC组的MRI动态强化特 征以环形强化为主，非TNBC组则以不均匀 强化为主，差异有统计学意义(P<0.05)； 两组TIC曲线类型比较，差异无统计学意 义(P>0.05)，但TNBC组多为流线型，非 TNBC组多为流出性及平台型；TNBC组的 病灶T2WI以高信号表现居多，且ADC值较 低，非TNBC组多为低信号，ADC值稍高， 差异均具有统计学意义(P<0.05)。结论 使用3.0T MRI技术可在无创条件下观察肿 瘤形态特征，有利于三阴性乳腺癌等恶性 肿瘤的鉴别，为后期临床治疗方案提供参 考。

Objective To observe the application of 3.0T MRI in the diagnosis of triple negative breast cancer and provide a reference for preoperative clinical diagnosis. Methods 110 cases of women with breast cancer admitted to our hospital from March 2015 to March 2018 were given retrospective analysis. According to the pathological examination results, patients were divided into triple negative breast cancer group (TNBC group, 42 cases) and non-triple negative breast cancer group (non-TNBC group, 68 cases). 3.0T magnetic resonance imaging diffusion-weighted imaging (MRI-DWI) was used for breast scan, and the pathological features (tumor number, size, shape, smooth edges or not, number of peripheral blood vessels, etc.) were compared between the two groups, and the MRI dynamic enhancement characteristics were observed in the two groups, and the time-signal intensity curve (TIC) types, T2WI signal intensity and ADC value were compared between the two groups. Results Compared with non-TNBC group, tumors were mostly round with smooth edges and increased peripheral blood vessels in TNBC group (P<0.05). The MRI dynamic enhancement was mainly based on annular enhancement in TNBC group while was mainly based on uneven enhancement in nonTNBC group (P<0.05). There was no significant difference in the TIC curve types between the two groups (P>0.05), but TNBC group was mostly with streamline type, and non-TNBC group was mostly with efflux and plateau types. The lesions in TNBC group were mostly high signal in T2WI with low ADC value, and the lesions in non-TNBC group were mostly low signal with slightly high ADC value (P<0.05). Conclusion 3.0T MRI technique can be used to observe the morphological characteristics of tumors in non-invasive conditions, and it is helpful for the identification of malignant tumors such as triple negative breast cancer, and provides reference for later clinical treatment regimen.