目的 探讨双源CT检查肺容积和 肺密度与慢性阻塞性肺疾病肺气肿患者肺 通气功能的相关性。方法 选取2015年1月 至2016年6月在河南中医药大学第一附属 医院就诊的COPD肺气肿患者102例进行研 究，抽取同期在我院健康体检者102例作 为对照组，2组患者均在3天内接受双源 CT和肺通气功能检测，记录患者全肺容 积(V)：Vin、Vex，肺容积差(Vin-Vex)， 肺容积比(Vex/Vin)；平均肺密度(MLD)： MLDin和MLDex，平均肺密度差(VD)；肺 总量(TLC)、残气量(RV)、用力肺活量 (FVC)、RV/TLC和第1秒用力呼气量与用 力肺活量百分比(FEV1/FVC)。结果 COPD 肺气肿组患者TLC、RV、RV/TLC、Vex、 Vin、Vex/Vin均较对照组显著升高(P均 ＜0.05)，FVC、FEV1/FVC、MLDin、MLDex 和MLDex-MLDin水平均较对照组显著降低 (P均＜0.05)。 Vin-Vex与RV/TLC、FVC 呈显著负相关，与FEV1/FVC呈正相关； Vex/Vin与RV、RV/TLC、FVC呈显著正相 关，与FEV1/FVC呈显著负相关；MLDexMLDin与TLC、RV、RV/TLC呈显著负相关， 与FVC、FEV1/FVC呈显著正相关，差异均 有统计学意义(P均＜0.05)。结论 双源CT 检测肺容积和肺密度与COPD肺气肿患者肺 通气功能指标有较好相关性，具有较高临 床价值。

Objective To investigate the correlation between dual-energy computed tomography (DECT) examination of lung volume and density of chronic obstructive pulmonary disease and lung function in patients with pulmonary emphysema. Methods 102 patients with COPD emphysema from January 2015 to June 2016 were enrolled, and 102 healthy subjects were selected as the control group, all patients received dual-source CT examination and pulmonary function test in 3 days, and the test results were recorded. Results COPD emphysema groups TLC, RV, RV/TLC, Vex, Vin, Vex/Vinwere significantly higher than the control group (P<0.05), FVC, FEV1/FVC, MLDin, MLDex and MLDex-MLDin levels were significantly lower than the control group (P<0.05). Vin-Vex and RV/TLC, FVC showed a negative correlation, positive correlation with FEV1/FVC. MLDex-MLDin and TLC, RV, RV/TLC showed a negative correlation, positive correlation with FVC, FEV1/FVC. Conclusion There is a good correlation between DECT detection of lung volume, density and the pulmonary function index of COPD emphysema patients , with a High clinical value.