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第二代双源CT双能量心肌灌注成像与SPECT心肌灌注的对照研究*

作者:朱红春 毛 俊 陈海东 任 旸 王兰菁

所属单位:暨南大学附属珠海医院(珠海市人 民医院)放射科 (广东 珠海 519000)

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摘要

目的 对比SPECT,探讨双源 CT(DSCT)双能量心肌灌注成像的临床应 用价值。方法 搜集18例临床怀疑冠心 病或已知冠心病史的患者行双源CT双能 量心肌灌注成像和静息/负荷心肌灌注 锝-99mSPECT显像检查,并对其影像表现 进行分析。结果 DSCT双能量心肌灌注成 像检查18例患者,发现阳性14例,阴性4 例。对比SPECT检查,14例DSCT阳性病例 中,SPECT均发现了相同心肌部位的灌注 缺损。而4例阴性病例中,SPECT检查有1 例有心肌缺血。二者检出心肌灌注缺损 的差异性无统计学意义(P>0.05)。结论 DSCT双能量心肌灌注成像发现心肌灌注缺 损的能力与SPECT大致相符,对冠心病的 诊断有较大价值。

Objective To evaluate the clinical value of the myocardial perfusion imaging dual-source CT (DSCT) dual energy, in the comparison of SPECT. Methods 18 cases of clinically suspected or known coronary artery disease were of collected. Then the patients underwent the myocardial perfusion imaging of DSCT and resting /loaded technetium99m SPECT.The imaging findings then were analyzed further. Results In 18 patients with DSCT dual energy myocardial perfusion imaging, 14 cases were positive, when 4 cases were negative. Compared with SPECT examination, the same cardiac perfusion defect of 14 positive cases were found in SPECT as in DSCT. Among 4 negative cases of DSCT examination, loaded SPECT detected myocardial ischemia in 1 case. Detection rates of cardiac perfusion defect between DSCT with SPECT showed no significant difference(P>0.05). Conclusion The myocardial perfusion imaging in DSCT dual energy possess the similar capability in myocardial perfusion defects with SPECT, and manifest great diagnosis value for coronary heart disease.

【关键词】心肌灌注;第二代双源CT;体 层摄影术;发射型电子计算机; 单光子

【中图分类号】R541.4;R445.3;R445.6

【文献标识码】A

【DOI】10.3969/j.issn.1672- 5131.2017.07.021

前言

冠状动脉粥样硬化性心脏病(CHD)在我国近年来发病逐渐增多并呈 年轻化趋势,其临床诊治及疗效评价,需评估冠脉血管及心肌灌注。 核素单光子CT扫描(single photon emission computed tomography, SPECT)心肌灌注显像(myocardial perfusion imaging,MPI)能反映 心肌静息和动态两个不同状态的血流灌注情况,是目前临床评价心肌 缺血的常用标准[1]。双源CT(dual-source CT,DSCT)具有两套球管和探 测器系统能同时进行两种不同能量的扫描[2],利用碘对比剂在正常心 肌组织和受损心肌组织的摄取存在差异性,经过计算双能量数据,把 碘对比剂在心肌组织内不同的分布情况用伪彩色表达出来,得到心肌 灌注图像即碘分布图[3]。第二代双源CT较前代具有选择性能谱纯化技 术,双能量模式区分碘的能力提高约80%,可显著降低辐射剂量,更 适合评价心肌灌注[4]。本研究通过自身前后对比SPECT心肌灌注显像, 探讨第二代DSCT双能量心肌碘分布图检出心肌灌注缺损的临床诊断价 值。