目的 探讨64排螺旋CT首过期灌 注成像在肺癌诊断中的临床价值。方法 选取2014年1月至2015年2月在我院治疗 的肺癌患者共106例，其中周围型肺癌63 例，中央型肺癌43例，分别以整个肿瘤、 肿瘤富强化区以及少强化区为感兴趣区 (ROIT、ROIR、ROIP)作时间密度曲线，计 算灌注量和强化峰值。结果 周围型非小 细胞癌ROIT、ROIR、ROIP 的灌注值和强 化峰值明显高于其他肿瘤，而中央型非小 细胞癌ROIT、ROIR、ROIP 的灌注值和强 化峰值明显低于其他肿瘤，差异有统计学 意义(P＜0.05)；直径≤5cm肿瘤，ROIT、 ROIR、ROIP的灌注值和强化峰值均高于 直径＞5cm的肿瘤，差异有统计学意义(P ＜0.05)；小细胞肺癌ROIP的平均强化峰 值为(10.36±3.03)HU，低于非小细胞癌 的(15.08±8.11)HU，差异有统计学意义 (P＜0.05)，其余指标差异无统计学意义 (P＞0.05)。结论 肿瘤灌注值和强化峰值 可能与肿瘤大小、位置相关，与病理类型 可能无相关性。

Objective To investigate the clinical value of 64 slice CT first phase perfusion imaging in the diagnosis of lung cancer. Methods A total of 106 cases of patients with lung cancer treated in our hospital from 2014 January to 2015 February were included in the study, 63 cases were peripheral lung cancer, 43 cases were central type lung cancer. The precontrast and postcontrast attenuation on the hole tumor(ROIT), rich blood supply area(ROIR) and poor blood supply area(ROIP) were recorded, to calculate the perfusion volume and the peak height. Results The ROIT、ROIR、ROIP perfusion volume and the peak height of peripheral non small cell cancer were obviously higher than that of other tumors, while the parameters of central type non-small cell cancer were obviously lower than that of other tumors, the difference was statistically significant (P<0.05). The ROIT、ROIR、ROIP perfusion volume and the peak height of tumors which the diameter were more than 5cm were higher than those of the tumors which the diameter were less than 5cm, the difference was statistically significant (P<0.05); the mean peak height of small cell lung cancer on ROIP was (10.36±3.03)HU, lower than the non small cell cancer (15.08 ±8.11) HU, the difference was statistically significant (P<0.05). Conclusion The perfusion volume and peak height of the tumor may be associated with the size and location, and may had no correlation with the pathological types.