目的 研究CT灌注成像(CTP)在短 暂性脑缺血发作(TIA)患者发作间期的应 用价值。方法 选取我院52例TIA患者为 研究对象并接受CTP检查，观察前、后循 环TIA患者灌注参数变化，包括达峰时间 (TTP)、局部脑血流量(rCBF)、局部脑血 容量(rCBV)、平均通过时间(MTT)，定量 分析CT灌注成像对TIA患者脑血流的诊断 价值。结果 前循环TIA 21例患者中灌注 异常率85.71%，灌注异常区rTTP、rMTT分 别为(15.11±1.74)s、(41.13±2.58)s， 与对侧正常区比较显著较高(P＜0.05)， 灌注异常区rCBF为(54.16±7.15) ml/100g·min与对侧正常区比较显著较 低(P＜0.05)，两组rCBV比较无统计学意 义(P＞0.05)；31例后循环TIA患者中灌 注异常率64.52%，后循环TIA患者灌注异 常区rTTP、rMTT分别为(13.25±1.25)、 (16.16±3.49)s与对侧正常区比较显 著较高(P＜0.05)，灌注异常区rCBF为 (50.34±2.44)ml/100g·min与对侧正常 区比较显著较低(P＜0.05)，两组rCBV比 较无统计学意义(P＞0.05)。结论 CT灌注 成像可观察短暂性脑缺血发作患者脑血流 状况，及时发现发作间期的脑灌注异常， 可用于早期病变患者血流动力学改变的观 察以及诊断。

Objective To study the application value of CT perfusion imaging (CTP) in seizure intervals of patients with transient ischemic attack (TIA). Methods 52 patients with TIA in our hospital were selected as the study objects. All of them underwent CTP. The changes of perfusion parameters in patients with anterior and posterior circulation TIA were observed, including the time to peak (TTP), regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) and mean transit time (MTT). The value of CT perfusion imaging in diagnosis of cerebral blood flow in patients with TIA was quantitatively analyzed. Results Of the 21 patients with anterior circulation, the rate of abnormal perfusion was 85.71%. RTTP and rMTT in abnormal perfusion region of patients with anterior circulation TIA [(15.11±1.74)s、(41.13±2.58)s] was significantly higher than that in the fellow normal region (P<0.05) while rCBF (54.16±7.15) ml/100g·min was significantly lower than that of fellow normal region (P<0.05). There was no significant difference in rCBV between the two groups (P>0.05); In 31 patients with posterior circulation TIA, the rate of abnormal perfusion was 64.52%. RTTP and rMTT in abnormal perfusion region in patients with posterior circulation TIA [(13.25±1.25), (16.16±3.49)] was significantly higher than that in the fellow normal region (P<0.05) while rCBF（50.34±2.44）ml/100g·min was significantly lower than that in fellow normal region (P<0.05). There was no significant difference in rCBV between the groups (P>0.05). Conclusion CT perfusion imaging can observe the cerebral blood flow in patients with TIA, and detect abnormal cerebral perfusion in seizure intervals of the attacks in time. It can be used in the observation and diagnosis of changes of haemodynamics in patients with early lesions.