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18F-FDG PET/CT对 卵巢癌患者术后复 发、转移的诊断敏 感性及准确性研究

作者:智生芳 毕 伟 黄晓红 李霞霞 张伟标

所属单位:广东省东莞市人民医院核医学科 (广东 东莞 523059)

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摘要

目的 探究并分析18F-FDG PET/CT 对卵巢癌患者术后复发、转移的诊断敏感 性及准确性。方法 选取2011年6月-2014 年6月本院收治的95例卵巢癌患者,对患 者进行全身18F-FDG PET/CT检查,并与单 纯CT检查结果对比,统计并分析18F-FDG PET/CT对卵巢癌患者术后复发、转移的诊 断敏感性及准确性。结果 两种方法检测 时灵敏度、特异度、阴性预测值、阳性预 测值无明显差异(P>0.05),不具有统计学 意义。单纯CT检测时准确性为71.12%, PET/CT检测时准确性为84.45%,明显高于 单纯CT检测(χ2 =3.89,P<0.05),具有统 计学意义。PET/CT诊断两组患者的灵敏 度、特异度、阴性预测值、阳性预测值比 较无明显差异(P>0.05),无统计学意义。 临床无复发组患者准确性、ROC AUC分别 为80.23、0.83,复发组患者准确性、ROC AUC分别为92.23、0.96,明显高于无复发 组患者(χ2 =4.87、5.64,P<0.05),具 有统计学意义,且18F-FDG PET/CT对于腹 膜转移的微小癌灶具有良好的诊断效果。 结论 PET/CT显像较单纯CT检查能更准确 的对卵巢癌术后复发、转移病灶进行判 定,为临床评估病情和制定治疗方案提供 一定帮助。

Objective To investigate and analyze the diagnostic sensitivity and accuracy of PET/CT 18F-FDG in the diagnosis of ovarian cancer recurrence and metastasis. Methods 95 cases of ovarian cancer patients treated in our hospital from June 2014 to June 2011, the patients were treated with PET/CT 18F-FDG and CT. The sensitivity and accuracy of PET/CT 18F-FDG in the diagnosis of recurrence and metastasis of ovarian cancer were analyzed. Results The sensitivity, specificity, negative predictive value and positive predictive value of the two methods were not significantly different (P>0.05). The accuracy of CT was 71.12%, and the accuracy of PET/CT was 84.45%, which was significantly higher than that of CT (χ2 =3.89, P<0.05). The sensitivity, specificity, negative predictive value and positive predictive value of PET/CT in the two groups were not significantly different (P>0.05), and had no statistical significance. The accuracy of AUC ROC and were 80.23 and 0.83, respectively, and the accuracy of AUC and ROC were 92.23 and 0.96, respectively, compared with those without recurrence group (χ2 =4.87, 5.64, P<0.05), with statistical significance. PET/CT 18F-FDG has a good effect on the diagnosis of small foci of peritoneal metastasis. Conclusion PET / CT imaging is more accurate than the simple CT examination to determine the recurrence and metastasis of ovarian cancer, and to provide help for clinical evaluation and treatment.

【关键词】18F-FDG PET/CT;卵巢癌;复 发或转移;诊断

【中图分类号】R445.3

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2016.02.032

前言

卵巢恶性肿瘤是女性生殖系统常见恶性肿瘤之一,在生殖系统肿 瘤中其发病率仅次于子宫颈癌和子宫体癌[1-2]。卵巢癌对患者身体危害 巨大,其死亡率仍然占各类妇科肿瘤的首位。目前,卵巢癌主要通过 手术治疗,部分患者在手术的基础上进行放疗、化疗等辅助治疗[3-4]。 近年来随着医疗技术的提升,其死亡率有所下降,但据临床数据显 示,5年生存率仅30%左右,这不仅与卵巢癌的恶性程度有关,卵巢癌 术后复发率以及转移率也是造成患者术后生存率低下的重要原因[5-6]。 因此,提高卵巢癌检查手段的准确度和敏感度是改善患者术后生存率 的重要手段之一。作为临床诊断常用的检查方式超声和CT对于卵巢癌 具有一定的诊断价值,但对于卵巢癌根治术的患而言,超声和CT对于 其复发和转移的诊断准确率仍有待提高。PET/CT是继超声和CT之后新 型的影像学诊断方法,其不仅融合了CT造影的图像,而且能根据组织 代谢情况突出显示异常代谢部位,从而达到诊断肿瘤的目的。为此, 本院对95例卵巢癌患者进行研究,现将报道如下。