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MR扩散加权成像和CT增强扫描技术在肝硬化分级诊断中的应用研究

作者:杨启顺

所属单位:广西壮族自治区南溪山医院影像科 (广西 桂林 541002)

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摘要

目的探讨MR扩散加权成像 (DWI)与CT增强扫描在肝硬化分级诊 断中的应用价值。方法 选取2013年1 月-2015年1月收入我院治疗的45例肝硬 化患者为研究对象,所有患者按照Child 进行分级,并采用DWI和CT增强扫描检 查,观察其不同b值(200,500,800s/mm2 ) 的表观扩散系数(ADC)与CT扫描结果。 结果 b=200,500s/mm2 时,不同肝硬化 Child分级组间ADC值比较,P<0.05, b=800s/mm2 时,不同肝硬化Child分级 组间ADC值比较,P>0.05;b=500s/mm2 时,不同肝硬化Child分级间两两比较, P<0.05。双动脉期增强扫描病灶检出率 为92.86%,单动脉期增强扫描病灶检出 率为86.11%。结论 DWI 在肝硬化诊断分 级中具有较好的诊断价值,可作为肝硬 化诊断分级的理想检查手段。而CT增强 扫描可提高小肝癌的检出率,但对患者 机体有辐射作用,因此,应根据临床目 的,选择适当的扫描方式。

Objective To explore the application value of MR diffusion weighted imaging (DWI) and CT enhancement scan in classification diagnosis of liver cirrhosis. Methods Forty five patients with cirrhosis admitted and treated in the Hospital from January 2013 to January 2015 were selected as research object, all patients were graded in accordance with Child, DWI and CT enhancement scan examinations were applied, apparent diffusion coefficient (ADC) and CT scan results with different b values (200,500,800s/ mm2 ) were observed. Results The comparisons in ADC values between different liver cirrhosis Child classification groups satisfied P<0.05 when b was denoted to be 200,500s/ mm2 , and the comparisons in ADC values between different liver cirrhosis Child classification groups satisfied P>0.05 when b was denoted to be b=800s/mm2 ; The pairwise comparisons in different Child inter-classifications with liver cirrhosis satisfied P <0.05 when b equaled to be 500s/mm2 . The positive rate of double arterial enhancement scanning lesion was 92.86%, and such value of single arterial enhancement scanning lesion was 86.11%. Conclusions DWI delivers better diagnostic value in the in diagnostic classification of cirrhosis, and it can be used as ideal examinations means for diagnosis classification of cirrhosis. And CT enhancement scan can improve the detection rate of small hepatocellular carcinoma, but such technique imposes radiation effect on the bodies of patients, therefore, appropriate scanning modes should be selected based on clinical purpose.

【关键词】MR Diffusion Weighted Imaging; CT Enhancement Scan; Diagnosis and Classification of Liver Cirrhosis

【中图分类号】R657.3+1

【文献标识码】A

【DOI】 10.3969/j.issn.1672- 5131.2016.02.023

前言

我国肝病人群较多。慢性肝病不断损伤与修复,在此过程中,细 胞外基质的合成增加,伴或不伴降解较少,导致肝细胞组织中细胞外 基质过度沉积,形成肝纤维化,进一步发展成为肝硬化,而肝硬化发 展成为肝癌的机率较高[1]。研究表明,在肝炎-肝硬化-肝癌的发展模 式中,肝硬化发展为原发性肝癌的可能性高达9.2%~28.6%[2]。因此, 肝硬化的早期诊断分级对及时采取治疗,改善预后具有重要意义。DWI 和CT增强扫描均为功能成像技术,在显示大体形态的同时可提供功能 改变的信息。本次研究采用两种成像技术对45例患者进行肝硬化诊断 分级,并比较两者的诊断结果,现报道如下。