目的 探讨70KV.50mAs多层螺 旋CT低辐射灌注扫描在肺癌诊治中应用 的可行性。方法 对发现肺部孤立性肿瘤 进行70KV.50mAs多层螺旋CT低辐射灌注 扫描。搜集有手术或穿刺病理证实45例 患者，鳞癌15例，腺癌23例，小细胞性 肺癌7例。利用体部肺肿瘤灌注软件对图 像进行后处理，根据非去卷积模型法获 得相应肿瘤灌注彩图，测定肿瘤的对比 剂达峰时间(TTP)、血流量(BF)、血容量 (BV)、渗透性(PMB)。结果 鳞癌、腺癌、 小细胞性肺癌的TTP(s)分别是：15.62、 17.91、16.89；鳞癌、腺癌、小细胞性肺 癌的BF(ml/100ml/min)分别是：91.72、 77.27、90.60；鳞癌、腺癌、小细胞性 肺癌的BV(ml/100ml)分别是：8.06、 8.94、11.94；鳞癌、腺癌、小细胞性肺 癌的PMB(ml/100ml/min)分别是：13.79、 15.17、13.95。结论 70KV.50mAs低辐射 灌注扫描方法能有效降低射线对患者的辐 射，该方法获得的肺部肿瘤的灌注数据可 以作为临床分析肺部肿瘤的血供及肿瘤血 液灌注的一种手段

Objective To investigate the clinical value and feasibility of low-dose 70kv.50mAs MSCT perfusion imaging in the evaluation of patients with lung cancer. Methods Retrospectively studied 45 cases(squamous carcinoma 15 cases, adenocarcinoma 23cases, small cell carcinoma 7cases) lung cancer confirmed by operation and pathology, these patients were undergone low-dose(70kv.50mAs)MDCT perfusion scanning before operation. The original images were processed by perfusion software. The value of time to peak(TTP), blood flow (BF), blood volume (BV) and permeability (PMB) were calculated, and gained perfusion image. Results The TTP (s) of squamous carcinoma, adenocarcinoma, small cell carcinoma were 15.62、17.91、16.89. The BF (ml/100ml/ min) of squamous carcinoma, adenocarcinoma, small cell carcinoma were 91.72, 77.27, 90.60;The BV (ml/100ml) of squamous carcinoma, adenocarcinoma, small cell carcinoma were 8.06, 8.94, 11.94. The PMB(ml/100ml/min)of squamous carcinoma, adenocarcinoma, small cell carcinoma were 13.79, 15.17, 13.95. Conclusion The lowdose(70kv.50mAs)MSCT perfusion scanning could gained good perfusion image and calculated tumor's value of TTP, BF, BV, PMB, it was a effective evaluation analysis for tumor's blood supply and perfusion.