目的探讨 3 . 0 T磁共振 T 2 * mapping成像技术定量分析膝关节骨性关 节炎的临床应用价值。方法 选取2012 年10月-2015年5月临床诊断为膝关节 骨关节炎患者46例，对照组为正常健 康志愿者7名。所有患者及对照组均行 基于FLASH(梯度回波)的多回波序列的 T2* mapping扫描。常规扫描均按照MRI 标准扫描规程进行。分别测量膝关节承 重面、非承重面软骨区，髌骨软骨关节 接触面与非接触面T2*值，比较不同程 度膝关节OA及膝关节不同部位T2*值的 差别。结果 正常成人、轻度OA、重度 OA膝关节软骨T2* mapping伪彩图表现 不同。正常成人膝关节承重面软骨T2* 值分别为股骨内侧髁(26.46±2.55)， 股骨外侧髁(26.51±1.21)，内侧胫骨 平台(23.10±2.19)，外侧胫骨平台 (25.36±3.17)；各部位差异无显著 性；非承重面软骨T2*值分别为股前 (34.36±6.18)，股后(38.08±7.07)。正 常组与轻度OA组、重度OA组承重面各测量 点T2*值比较差异有显著性(P＜0.05)，轻 度OA组与中度OA组承重面各测量点T2*值 比较差异有显著性(P＜0.05)。结论 膝关 节软骨T2*mapping可早期提示膝关节软骨 损伤、变性，并可通过T2*值对膝关节OA 程度进行评估。

Objective To evaluate the clinical value of 3.0 T MRI T2* mapping quantitative analysis for diagnosis of knee osteoarthritis. Methods The study group included forty-six patients (thirty-two males and fourteen females) with knee osteoarthritis, average age was 41.2±15.5 years. Seven normal healthy volunteers attended as control group. All patients and controls underwent T2* mapping imaging based on FLASH (gradient echo) of the multi-echo sequence. T2* value of knee cartilage of each compartment was measured, T2* value of cartilage of normal control group, mild OA group and severe OA group on different knee compartments were compared, respectively. Results T2* mapping imaging could display the different performance between normal adult, mild OA, severe OA knee cartilage. T2* value of bearing surface of normal adult knee cartilage was medial femoral condyle (26.46±2.55), the lateral femoral condyle (26.51±1.21), the medial tibial plateau (23.10±2.19) and the lateral tibial plateau (25.36±3.17), respectively, no significant difference between all parts of them (F=3.72, P>0.05). T2* value of forepart and posterior part of condyle cartilage were (34.36±6.18) and (38.08±7.07), respectively. All cartilage compartments of bearing surface showed significant increase (P<0.05) in T2* value between normal control group, mild OA group and severe OA group. No significant difference (P>0.05) was found between normal group, mild OA group and severe OA group on non-load-bearing surface and the patellar cartilage in T2 * values. Conclusion MRI T2* mapping quantitative analysis may provide early evidence of articular cartilage damage, degeneration, and assess the degree of knee OA.