目的评估普美显(Gd-EOB-DTPA) MRI增强肝胆期对肝硬化结节与小肝癌的 鉴别与定性的价值。方法 20例肝硬化病 人行MRI平扫、普美显动态增强扫描及增 强扫描肝胆期扫描，对磁共振图像进行分 析，所有病例于磁共振检查后在4周内进 行穿刺活检或手术得出病理结果，影像诊 断与病理结果对照。结果 20例肝硬化病 人的86个结节中，常规平扫和动态增强扫 描检出小肝癌17例。增强扫描肝胆期检出 小肝癌21例。通过肝胆期扫描，对小肝癌 的敏感性及特异性、精确度均有提高，其 中3个恶变结节仅在肝胆期具有特征性。 结论 对肝硬化再生结节/增生结节与早期 肝细胞肝癌，肝胆期的敏感度及精确度高 于动态MRI增强扫描。普美显磁共振增强 扫描能早期检出有恶变倾向的肝硬化结节 和小肝癌。建议在肝硬化病人影像检查中 应广泛应用普美显的MRI增强检查。

Objective To assess the value of the identification and characterization of GdEOB-DTPA -MRI enhanced Hepatobiliary phase which have effect on cirrhosis nodules and small hepatocellular carcinoma. Methods Twenty patients of cirrhosis who had MRI scan, Gd-EOB-DTPA dynamic enhanced scan and Hepatobiliary stage enhanced scan. Magnetic resonance images were analyzed, all patients who had Magnetic resonance imaging (MRI) will have biopsy or surgical pathology results within 4 weeks. Besides, imaging diagnosis and surgical pathology results were control. Results 86 nodules were detected in twenty patients of cirrhosis, 17 cases of small hepatocellular carcinoma were detected through conventional unenhanced scan and enhanced scan while 21 cases of small hepatocellular carcinoma were detected. Through Hepatobiliary phase enhanced scan , the sensitivity and specificity of small hepatocellular carcinoma had improved, which has only three characteristics of malignant nodules in the liver and gallbladder period. Conclusion Contrast to cirrhosis nodular regenerative/hyperplastic nodules and early HCC, the sensitivity and accuracy of Hepatobiliary phase enhanced scan are higher than dynamic enhanced MRI scan. Gd-EOB-DTPA－enhanced MRI scan can early detect malignant nodules and cirrhosis of liver cancer. Gd-EOB-DTPA is recommended to apply to enhancement MRI examination in patients with cirrhosis.