目的通过比较膝关节骨髓信噪 比(SNR)和对比噪声比(CNR)，探讨3.0T磁 共振常规T1加权像(T1-sag)、三维容积内 插快速扰相序列(T1-vibe)、质子密度加 权像(PD-sag)和常规T2加权脂肪抑制像 (T2-fs-sag)4种扫描序列对膝关节骨髓损 伤成像的相对最佳序列。方法 选取我院 2014年1月至2014年6月行膝骨关节骨髓磁 共振检查膝骨关节炎患者36例，均行T1- sag、T1-vibe、PD-sag和T2-fs-sag扫描。 结果 采用T1-sag、T1-vibe、PD-sag和 T2-fs-sag序列扫描时，膝骨关节骨髓SNR 分别为111.82±61.39、14.53±4.73、 77.57±39.98和189.44±89.98；CNR分 别为194.27±92.43、14.08±15.39、 79.23±40.29和153.29±81.40；采用 T2-fs-sag扫描时的SNR最高，其次为T1- sag序列、PD-sag序列，T1-vibe序列扫描 时的SNR最低；采用T1-sag扫描时的CNR 最高，其次为T2-fs-sag序列、PD-sag序 列，T1-vibe序列扫描时的CNR最低。结论 MR序列膝关节骨髓成像可为临床提供关节 骨髓病变信息，T2-fs-sag和T1-sag序列是 显示膝关节骨髓损伤的优秀序列。

Objective To compare SNR and CNR of bone marrow changes of knee osteoarthritis between four sequences, such as T1-sag, T1-vibe, PD-sag and T2-fssag, so as to find out the optimal sequence to diagnose the disease. Methods 36 patients suffering knee osteoarthritis were selected to perform T1-sag, T1-vibe, PD-sag and T2- fs-sag scanning between January to June, 2014 in our hospital. Results The values of SNR were 111.82±61.39, 14.53±4.73, 77.57±39.98 and 189.44±89.98 respectively, when scanned by T1-sag, T1-vibe, PD-sag and T2-fs-sag sequences. And the values of CNR were 194.27±92.43, 14.08±15.39, 79.23±40.29 and 153.29±81.40 respectively. The value of SNR was highest when scanned by T2-fs-sag, and then followed by T1-sag, PD-sag and T1-vibe. The value of CNR was highest when scanned by T1-sag, and then followed by T2-fs-sag, PD-sag and T1-vibe. Conclusion MR sequences imaging could offer information of bone marrow changes of knee osteoarthritis, and T2-fs-sag and T1- sag might be the relative optimal sequences to diagnose the disease.