目的评价18F-FDG PET-CT显像对 黑色素瘤患者综合治疗后随访的诊断及其 预后的价值。方法 对我院40例黑色素瘤 综合治疗的患者，回顾18F-FDG PET-CT显 像和常规影像学诊断结果，采用SPSS13.0 统计学软件包进行统计分析，计数资料采 用四格表的方法计算阳性预测值、阴性预 测值、灵敏度、特异度、准确性、假阳 性率、假阴性率。结合18F-FDG PET-CT与 相应组织病理定性诊断，以ROC曲线确定 黑色素瘤病灶最佳SUVmax。通过建立以性 别、年龄、病灶SUVmax、治疗方法、淋 巴结转移情况、病灶部位COX比例风险回 归模型，分析影响整体生存率的因素。 结果 40例黑色素瘤患者18F-FDG PET-CT 显像诊断的阳性预测值90%、阴性预测值 100%、灵敏度86%、特异度96%、准确性 90%；常规影像学诊断阳性预测值79%、阴 性预测值72%、灵敏度65%、特异度78%、 准确性73%%；黑色素瘤病灶最佳SUVmax为 2.5；COX比例风险回归模型分析显示，病 灶SUVmax(相对危险度RR=1.312,P=0.009) 和淋巴结转移情况(RR=2.815,P=0.004)是 影响整体生存率主要因素。结论 18F-FDG PET-CT显像对黑色素瘤患者综合治疗后的 诊断比常规影像学具有较高的灵敏度、特 异度、准确性，对预后的评估具有重要价 值。

Objective To evaluate 18F-FDG PET-CT imaging to the diagnosis of melanoma patients comprehensive follow-up after treatment and prognostic value. Methods A total of 40 cases of melanoma patients with comprehensive treatment, review of 18F-FDG PET-CT imaging and conventional imaging diagnosis, to statistical analysis using SPSS13.0 statistical software package, count data using four case table method to calculate positive predictive value, negative predictive value, sensitivity, specific, accurate, false positive rate and false negative rate. In combination with 18F-FDG PET-CT and histopathological corresponding qualitative diagnosis, with ROC curve to determine the optimal SUVmax melanoma lesions. Through the establishment of gender, age, focal SUVmax, treatment, lymph node metastasis, lesion COX proportional hazards regression model, analyze the influencing factors of overall survival. Results 40 cases of melanoma patients 18F-FDG PET-CT imaging in the diagnosis of the positive predictive value of 90% and negative predictive value of 100%, 86%, 96%, specific sensitivity, accuracy of 90%; Conventional imaging in the diagnosis of positive predictive value, negative predictive value of 79%, 72%, 73%, 65%, 65% sensitivity, specific, accurate %; Melanoma lesions best SUVmax is 2.5; COX proportional hazards regression model analysis showed that lesions SUVmax (relative risk, RR=1.312, P=0.009) and lymph node metastasis (RR=2.815, P=2.815) is the main factor that affect the overall survival rate. Conclusion 18F-FDG PET-CT imaging to the diagnosis of melanoma patients after comprehensive treatment than conventional imaging has high sensitivity, specific, accurate, important value to the evaluation of prognosis.