论著-头颈部
肝癌介入治疗中磁共振弥散加权成像技术的作用研究*
作者:侯毅斌 王忠富 戴志京 陈国硕 陈志军 邱丛坤 汤日杰
所属单位:广州医科大学附属肿瘤医院放射科(广东 广州 510093)
PDF摘要
目的研究探讨肝癌介入治疗 中磁共振弥散加权成像技术的临床作用 及应用价值。方法 选取我院收治的确 诊为肝癌并行介入治疗的患者23例作为 研究对象,分别在介入治疗前和治疗后 7d的时间点对患者行常规平扫和核磁共 振弥散加权成像扫描,观察患者的影像 学特征,测定并比较在不同的扩散敏感 梯度值(b值)下肿瘤区域的平均ADC值。 结果 肝癌病灶位置呈中高信号或者高 信号,治疗结束一周之后,T2WI上病灶 区域的内有点状或者片状低信号,DWI 上以低信号为主。治疗前后的肿瘤组 织体积分别为(203.92±121.88)cm3 和 (146.38±118.29)cm3 。比较有统计学差 异,且P<0.05。b=1000s/mm2 和1300s/mm2 的时候,图像质量较差,无法测量得到 准确地ADC值。b=50s/mm2 和100s/mm2 时, 治疗前后的平均ADC值比较无统计学差 异(P>0.05)。b=300s/mm2 、500s/mm2 和 700s/mm2 时,平均ADC值随着b值得升高而 升高,且治疗前后的平均ADC值之间的比 较有统计学差异(P<0.05)。结论 磁共振 弥散加权成像能够对肿瘤形态的微观变化 进行有效的反映,选择合适的扩散敏感梯 度值选择能够获得较好的信号对比度,可 以通过对细胞密度、肿瘤血管密度等的变 化情况反映肝癌患者介入治疗后的病理生 理变化,评估治疗效果,值得临床推广应用。
Objective To study magnetic resonance diffusion weighted imaging in the interventional therapy of liver cancer clinical effect and application value. Methods Our hospital diagnosed with liver cancer interventional treatment of patients with 23 cases as the research object, respectively in the interventional treatment before and after treatment the timing of the 7 d for patients undergoing routine scan and magnetic resonance diffusion weighted imaging scans, observe the imaging characteristics of patients, and compare the different diffusion sensitive gradient value (b) the average ADC values of tumor area. Results The liver lesion location has high signal or high signal, a week after the end of the treatment, lesion area on T2WI with dot or flake low signal, DWI is given priority to with low signal on the can. Before and after treatment of tumor volume, respectively (203.92+121.88) cm3 and cubic centimeter (146.38-118.29). Comparing statistically significant, and P<0.05. B=1000 s/s/was and 1300 was when the image quality is poorer, ADC values cannot be measured accurately. B=50 s/s/was and 100 was the average ADC values before and after the treatment is no statistical difference (P>0.05). B= 300 s/s/was 500 and 700 was, s/was, on average, ADC values increase with b is increasing, and the average ADC values before and after the treatment the comparison between statistically significant (P<0.05). Conclusion Magnetic resonance diffusion weighted imaging can reflect the microscopic changes in the form of tumor effectively, select the appropriate diffusion sensitive gradient value choice to obtain a better signal contrast, can be based on the change of cell density, the density of tumor blood vessels in patients with hepatocellular carcinoma after interventional therapy of pathological physiological changes, assessment of therapeutic effect, worthy of clinical popularization and application.
【关键词】磁共振弥散加权成像;肝癌; 介入治疗;临床作用
【中图分类号】R735.7
【文献标识码】A
【DOI】10.3969/j.issn.1672-5131.2015.02.14
前言
原发性肝细胞癌是我国常见的恶性肿瘤之一,多数在肝硬化的基 础上发生,降低肝癌死亡率、提高肝癌患者生存率的关键是肝癌早期 发现和早期治疗[1-2]。临床上治疗肝癌的最有效也最常使用的方法就是 介入资料。而随着影像学检查技术的不断发展,磁共振扫描成像技术 在疾病的诊断与评估中也发挥着越来越重要的作用。磁共振弥散加权 成像技术就能通过治疗前后病灶的体积与微观结构的观察,来评估治 疗的效果。本文就我院收治的行肝癌介入治疗的患者作为研究对象, 探讨磁共振弥散加权成像技术的应用价值。具体报告如下。
中国CT和MRI杂志
第13卷, 第 2 期
2015年02月
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