目的探讨胃癌患者胃癌多层螺 旋CT灌注成像及灌注参数与肿瘤因子的相 关性。方法 随机选择我院肿瘤科2010年 1月至2012年9月收治的32例胃癌患者作 为观察组、体检中心随机选取的健康研 究对象40例作为对照组，对两组研究对象 均采用CT灌注成像检测，比较两组研究 对象的CT灌注成像经灌注软件包处理后 的血流量(Perfusion)(即单位时间内每 100g肾组织内通过的血液量)、血容量(即 100g肾组织内的血液容量(BV))，峰值强 化(PEI)，达峰时间(TTP)，平均通过时间 (MTT)，表面通透性(PS)及相关肿瘤因子 水平差异，并采用Pearson相关分析法分 析CT灌注参数与肿瘤因子的相关性。结果 观察组和对照组Perfusion、PEI、TTP、 PS比较差异具有统计学意义(p<0.05)； 两组间BV、MTT比较差异不具有统计学意 义(p>0.05)；观察组的肿瘤因子CEA、 AFP、CA199、CA72-4水平均显著的高于对 照组且差异具有统计学意义(p<0.05)； Perfusion、PEI、PS与肿瘤因子CEA、 AFP、CA199、CA72-4呈显著的正相关性， TTP与肿瘤因子CEA、AFP、CA199、CA72-4 呈显著的负相关性。结论 通过对胃癌患 者胃癌进行多层螺旋CT灌注成像检测，可 以有效分析肿瘤因子的水平，两者间存在 良好的相关性。

Objective To explore the correlation between gastric cancer multi-slice spiral CT perfusion imaging and perfusion and tumor factor. Methods 32 cases of gastric cancer patients random selected from Department of oncology in our hospital from 2010 January to 2012 September as the observation group, 40 cases healthy subjects randomly chosen in the physical examination center as control group, the two groups of subjects were using CT perfusion imaging, compared blood flow perfusion software into the packet processing after the CT perfusion (Perfusion)(blood volume or per unit time per 100gin renal tissue)、blood volume (100g in renal tissue of blood within the capacity of (BV))、 peak enhancement (PEI), time to peak (TTP),mean transit time (MTT), permeability surface (PS) differences and related tumor factor levels of two groups, and analyzed the correlation between CT perfusion parameters and tumor factor by using Pearson analysis method. Results The observation group and the control group Perfusion, PEI, TTP, PS with significant difference (p<0.05) between the two groups; BV, MTT difference was not statistically significant (p>0.05); observation group tumor factor CEA, AFP, CA199, CA72-4 levels were significantly higher than those in the control group and the difference was statistically significant (p<0.05); Perfusion, PEI, PS and tumor factor CEA, AFP,CA199, CA72-4 there is a significant positive correlation between TTP and tumor factor, CEA, AFP, CA199, CA72-4 showed a significant negative correlation between. Conclusion Multi-slice spiral CT perfusion imaging in detection of gastric cancer can effectively analyze tumor factor level, there is a good correlation between them.