Objective To analyze the clinical and imaging features of skull base-type pituitary adenoma. Methods The clinical data of 118 patients with skull base-typepituitary adenoma who were admitted to the hospital from June 2013 to December 2017were collected. All patients were examined by MRI and confirmed by surgery and pathology. Data such as demographic characteristics, clinical symptoms, results of endocrine examination, postoperative pathological findings and hypopituitarism were collected and analyzed, and MRI findings were analyzed. Results The main symptoms of patients with skull base-type pituitary adenoma were fading eyesight, headache and dizziness. They were secondary symptoms such as acromegaly, back pain and irregular menstruation. Most of the pathological types were prolactinoma and somatotropinoma, followed by gonadotrophin adenoma, adrenocorticotropic hormone adenoma, thyroid stimulating hormone adenomaand multi-hormone adenoma. Most of the patients had large adenomas with or without hypopituitarism. The size of tumors was closely related to the pathological type of pituitary tumors (P<0.05), but not significantly correlated with hypopituitarism (P>0.05).MRI showed the skull base-type pituitary adenomas were round or oval, with clear and smooth edges, which were masses with equal density or high density. There was sellar floor tumor destruction invaded sphenoid sinus, hourglass sign because of breakthrough growth, patchy calcification, high-density hematoma and necrotic or cystic signal. T1WI showed low and equal signal, while T2WI showed slightly high or high signal. Dynamic enhancement scanning showed inhomogeneous enhancement. Conclusion There are typical characteristics of skull base-type pituitary adenomas in terms of clinical symptoms, pathological types and imaging findings. MRI can clearly show the size, shape, hemorrhage, calcification and growth of tumors, which is important for preoperative diagnosis of skull base-type pituitary adenoma.