Objective To investigate the application value of non-contrast CT (NCCT) in the outcomes prediction of extracorporeal shock wave lithotripsy (ESWL) for renal stone, and to provide a theoretical basis for the curative effect prediction of ESWL. Methods In this study, 120 patients with renal stone underwent ESWL in our hospital from April 2016 to April 2017 were enrolled. The CT value ranges of the soft tissue window were determined by NCCT, patients were divided into three groups according to the CT values, namely low-density group (49 cases), middle-density group (36 cases), highdensity group (35 cases) with CT values ranging from ≤ 500 HU, 500 -1000 HU, ≥ 1000 HU respectively. All patients underwent ESWL, and the stone crushing rate, the sessions of lithotrispy and shock wave number were recorded and compared among the three groups. Results The low-density group had the lowest invalid rate, calculi residual rate, and the highest efficiency rate, the comparison of the invalid rate, calculi residual rate and efficiency rate among three groups showed a significant difference, moreover the paired comparison showed statistic difference(P<0.05). The stone free rate of the lowdensity group was the highest, which was significantly higher than that of the middle and high-density group(P<0.05), no statistic difference was found between the middle and high density group(P>0.05). The shock wave number, sessions of lithotrispy and CT values was lowest in the low-density group, the difference of the three groups was significant, and the paired comparison had statistically significant difference(P<0.05). Conclusion The curative effect of ESWL for renal stone varies with the CT value, suggesting that the application of NCCT can predict the curative effect of ESWL, and provide a theoretical basis for the treatment of renal stone.