Objective To investigate the value of multi-slice CT (MSCT) three-phase enhanced scan in the diagnosis of renal tumor-like lesions. Methods A total of 52 patients with pathologically confirmed renal tumor-like lesions in our hospital from September 2015 to September 2016 were selected. All patients underwent CT scan and enhanced scan. The clinical and imaging data of 52 patients were sorted out. According to the results of pathological examination, the diagnostic accuracy of phase III enhanced CT in renal neoplasia was analyzed. Two veteran radiologists diagnosed the image of CT scan and contrast-enhanced scan, and analyzed the imaging features of renal tumor-like lesions. Results The pathological examination showed that in 52 patients, there were 27 cases of renal cell carcinoma, 19 cases of renal papilloma, 2 cases of sarcoma and 4 cases of other cases. Using CT scan, the detection rate of lung cancer in 52 patients was 94.23% (49/52). There were 26 cases of renal cell carcinoma detected, 18 cases of renal papilloma, 2 cases of sarcoma and 3 cases of others. There was no significant difference in the diagnosis of renal tumor-like lesions between CT enhanced scan and pathological examination (χ2 =0.045, P=0.832). CT plain showed lesions mostly equal density or slightly lower density, very few lesions appear slightly higher density. Patients with renal lesions in the three dynamic CT enhanced scan image was significantly enhanced, and lesions around the boundaries and the boundaries show clearly. Conclution The three-phase dynamic contrast-enhanced scanning (CT) images can provide an accurate and comprehensive visualization of the lesion area and have a high diagnostic accuracy for neoplastic tumorlike lesions. It is helpful for the imaging doctors to accurately locate and display the lesion site, which may be clinically important Imaging information to help clinicians diagnose and guide clinicians to develop the correct treatment options, it is worth clinical promotion and application.