Objective To study the diagnostic value of morphological feature score combined with energy spectrum parameters CT in solitary pulmonary nodules (SPN). Methods 46 patients with SPN confirmed by pathological findings in the hospital during February 2013 to May 2015 were treated as the research objects. According to the pathological findings, the patients were divided into the malignant nodule group and the benign nodule group. All patients underwent CT examination. The images were analyzed by professional workstation and the morphological features of pulmonary nodules were displayed. Meanwhile, the energy spectrum analysis was performed on the energy spectrum browser. The morphological features and energy spectrum parameters were effectively combined to evaluate the sensitivity, specificity and accuracy. Results The subjective score of morphological features and comprehensive score of the malignant nodule group were (4.23±0.12) and (4.14±0.21) points which were significantly higher than(2.07±0.21) and (2.41±0.22) points of the benign nodule group, respectively. The differences were statistically significant (P＜0.001). The results of morphological feature score combined with energy spectrum analysis showed that the sensitivity, specificity and accuracy of scheme one in the diagnosis of APN were 98.4%, 91.7% and 96.0%, respectively while those of scheme two were 96.9%, 88.9% and 94.0%, respectively and of scheme three were 92.2%, 80.6% and 88.0% respectively. Conclusion Morphological feature score combined with energy spectrum CT parameters is of significant value in the diagnosis of APN and the sensitivity, specificity and accuracy are relatively high.