Objective To explore the differential diagnosis value of dynamic contrastenhanced MRI (DCE-MRI) quantitative parameters of benign and malignant breast tumors. Methods 14 cases with benign breast tumors, 24 cases with malignant breast tumors confirmed by operation, underwent the examination of DCE-MRI. ROI were drawn to record the quantitative parameters average values of Ktrans, Kep, Ve. The quantitative parameters between benign and malignant breast tumors were compared by independent samples t-test. The areas under the ROC curve of the quantitative parameters between benign and malignant breast tumors were compared. Results The average values of Ktrans, Kep, Ve in benign breast tumors were (0.134±0.121) min-1, (0.273±0.137) min-1, (0.633±0.096). The average values of Ktrans, Kep, Ve in malignant breast tumors were (0.339±0.128) min-1, (0.515±0.169) min-1, (0.680±0.116). The difference of Ktrans, Kep between benign and malignant tumors were statistically significant (P ＜0.001). The difference of Ve between benign and malignant tumors was not statistically significant (P=0.213). Using the maximum Youden index as the cut-off value, the sensitivity of Ktrans, Kep were 89.17%, 93.83%. The specificity of Ktrans, Kep were 94.56%, 85.71%. The area under the ROC curve of Ktrans, Kep were 0.929, 0.902. Conclusion The differential diagnosis of benign and malignant breast tumors by quantitative parameters Ktrans, Kep were applicable.