Objective To investigate the clinical application of hepatic perfusion imaging of 64-slice spirl CT in schistosomiasis cirrhosis. Methods 64-slice spirl CT hepatic perfusion imaging in 76 cases, inside, mild schistosomiasis cirrhosis in 20 cases,moderate schistosomiasis cirrhosis in 18 cases and severe schistosomiasis cirrhosis in 25 cases, healthy volunteers and other diseases underwent abdominal CT examination in 13 cases for control group.Measurement of liver perfusion parameters,include the blood volume(BV),blood flow(BF), contrast agent mean transit time(MTT),hepatic arterial fraction(HAF)and hepatic arterial infusion (HAP),liver cirrhosis grading analysis of different liver perfusion parameters in different groups. Results Control group、mild schistosomiasis cirrhosis group, moderate schistosomiasis cirrhosis group, severe schistosomiasis cirrhosis group, The BV, BF value decreased gradually with the increased degree of schistosomiasis cirrhosis, the difference between the groups was statistically significant (P values were less than 0.01). Above each group the MTT, HAF, HAP value increased gradually with the increased degree of schistosomiasis cirrhosis, the difference between the groups was statistically significant (P values were less than 0.05), The relationship between BF and BV was negatively correlated with the severity of schistosomiasis cirrhosis,and the relationship MTT、HAF and HAP was positively correlated with the severity of schistosomiasis cirrhosis. Conclusion 64-slice spirl CT perfusion imaging parameters can reflect the hemodynamic changes of the schistosomiasis cirrhosis of the liver in each group,there is a certain value for the clinical assessment of the schistosomiasis cirrhosis, the early diagnosis and treatment of the schistosomiasis cirrhosis and the effect of the observation have great value.