Objective To explore evaluation function of CT scan and three-dimensional reconstruction technique in the changes of width of pedicle in patients with osteoporotic vertebral compression fractures. Methods A retrospective analysis of clinical data was carried out in fracture patients treated in department of orthopedics of our hospital from April 2013 to April 2016. Patients with osteoporotic vertebral compression fractures (n=58) were divided into group A, patients with thoracolumbar fracture were divided into group B (n=46). POW value in two sides of vertebrae, POW value in vertebrae in group A and group B were compared, incidence of tiny vertebral pedicle in group A and group B were calculated. Results There was no significant difference in POW measured value in two sides of vertebrae in 58 patients (P>0.05). POW in T11-L3 in group A were significantly higher than group B (P<0.05). There was no significant difference in POW in L4 and L5 compared with group B (P>0.05). Conclusion Application of CT scan and threedimensional reconstruction technique can measure patients' width of pedicle effectively in patients with osteoporotic vertebral compression fractures, thus evaluating feasibility of percutaneous vertebroplasty and pedicle for screw placement, and provide direction for operation.