Objective The value of the clinical diagnosis of by CT and MRI detected in nasal inverted papilloma. Methods A retrospective analysis of our hospital from June 2012 to November 2015 period pathologically confirmed nasal cavity and paranasal sinuses inverted papilloma 100 cases of tumor patients, preoperative CT and MRI were compared with analysis of CT and MRI pathological diagnosis (gold standard) compliance rates, and analyze the characteristics of imaging diagnosis of CT and MRI. Results The pathological examination site of origin 100% detection rate significantly higher than the 85% CT and pathologic examination stage detection rate of 100% was significantly higher than the 83% CT, more significant differences (P<0.05), the detection rate of malignant disease detection CT75% 100% and no significant difference (P>0.05), detection of malignant disease detection rate of 100% was significantly higher than 25% MRI, the difference was significant (P<0.05), pathological examination site of origin and the detection rate of 100% MRI of 97% was no difference in disease detection stage 100% detection rate of 94% compared with MRI little difference (P>0.05). CT malignancy detection rate of 75% was significantly higher than the 25% MRI, CT origin site inspection the rate of 85% was significantly lower than that of MRI 97%, CT staging detection rate of 83% was significantly lower than 94% MRI, and there were significant differences (P<0.05). Conclusion CT combined with MRI, can show full of nasal inverted papilloma scope and boundaries of the surrounding soft tissue, helps preoperative clinical stage and accurate assessment of tumor origin, and thus more conducive to early diagnosis, early treatment.