Objective To explore the effect of dynamic contrast-enhanced MRI (DCEMRI) in the prognosis evaluation of patients with nasopharyngeal carcinoma treated by chemoradiotherapy. Methods 77 patients with nasopharyngeal carcinoma confirmed by nasopharyngeal fiberscope pathological biopsy in our hospital during January 2011 to December 2014 were selected in this study, all the patients were collected related parameters by DCE-MRI before chemoradiotherapy, it including Positive Enhancement Integral (PEI), maximal slope increasing (MSI), maximal slope descending (MSD), tmax (TTP) and so on. At the same time the expression of HIF-1α was assayed by immunohistochemical staining, using of Kaplan-Meier curve analysis of survival rate. Results The positive rate of HIF-1α was 75.57％. The remission rate, control rate and survival rate were significantly reduced, tumor metastasis rate was significantly increased of HIF-1α alpha positive patients than HIF-1α alpha negative patients(P<0.05). Otherwise, the 1,2,3 years of recurrence free survival rate was less of HIF-1αalpha positive patients than HIF - 1 alpha negative patients(P<0.05). The MSD、PEI、MSI and TTP were significantly increased of HIF-1α alpha positive patients than HIF-1α alpha negative patients(P<0.05). Conclusion DCE-MRI parameters correlated with HIF1α highly positive, it indicates that chemotherapy in patients with nasopharyngeal put poor prognosis, and it has an important value for the prognosis evaluation of patients with nasopharyngeal carcinoma.