Objective To investigate the application value of CT angiography (CTA) in the diagnosis of aortic dissection (AD) and the evaluation for the curative effect on interventional therapy. Methods The clinical data of 36 patients with AD admitted to the hospital from January 2015 to December 2017 were analyzed retrospectively. All patients underwent DSA and CTA examination. The accuracies of CTA for the diagnosis of the primary break location of AD patients and Debakey types were evaluated. The value of CTA in the evaluation for the curative effect on AD interventional therapy was analyzed. Results Taking the DSA diagnosis results as the golden standard, the accuracy of CTA in the diagnosis of primary break location of AD patients was 86.11%. The overall accuracy of CTA in the diagnosis of Debakey types of AD patients was 97.22%. A total of 25 AD patients of Debakey III type were given transluminal stent-graft placement. After 2 weeks of the surgery, CTA reexamination found there were 7 acute cases with type I proximal endoleak. The patients were self-healing after given medical conservative treatment. Among the remaining 12 cases with acute AD and 6 cases with chronic AD, CTA reexamination after 2 weeks of the surgery found that there was thrombosis in the pseudocoele but no complications. The success rate of surgery and the recent mortality were 100% and 0, respectively. There was 1 case died after 6 months of surgery by followup. And the mortality was 4.00%. Conclusion CTA is of great value in the diagnosis of AD. It can provide important reference information for the short-term curative effect evaluation of AD patients after interventional therapy in clinical practice.