Objective To investigate the differences in the application value of CT and MRI in the clinical staging of prostaticcancer. Methods 124 patients with prostaticcancer comfirmed by surgical and pathological examination who were treated in the hospital during June 2012 to April 2015 were selected as the research objects.All of them received CT and MRI examination before operation. The results of the examinations weredetailedly recorded and analyzed. The results of postoperative pathological staging were taken as the gold standard to evaluate the differences in coincidence rates of CT and MRI staging. Results The results of surgical and pathological staging showed that among the 124 patients with prostaticcancer, there were 23 cases at stage A(18.5%), 28 cases at stage B(22.6%), 42 cases at stage C(33.9%) and 31 cases at stage D(25.0%). Taking the results of surgical and pathological staging as the gold standard, it indicated that there were 18 cases at stage A(78.3%), 21 cases at stage B(75.0%), 36 cases at stage C(85.7%) and 27 cases at stage D(87.1%) correctly diagnosed by MRI. There were 10 cases at stage A(43.5%), 13 cases at stage B(46.4%), 35 cases at stage C(83.3%) and 26 cases at stage D(83.9%)correctly diagnosed by CT. There was no statistical significance in the comparison of accuracy at stage C and D between the two methods(P＞0.05). At stage A and B, the diagnostic accuracy of MRI staging was significantly higher than that of CT and the difference was statistically significant (P＜0.05). Conclusion The staging accuracy of MRI examination in patients with prostaticcancer at stage A and B was higher than that of CT, which can be used in the preoperative staging evaluation of patients with prostatic cancer and provide basis for making treatment plan. It is worthy of promotion.