Objective To analyze the clinical and imaging features of solitary plasmacytoma of spine (SPS). Methods The clinical and imaging data of 15 cases of SPS confirmed by surgery and pathology were retrospectively analyzed. The clinical and imaging features of SPS were summarized. Results The first-episode manifestations of SPS were pain of the diseased spine and peripheral pain and the pain gradually increased with the aggravation of the disease, often complicated by the symptoms and characteristics of nerve or spinal cord. The X-ray images of 15 cases of SPS patients showed features of destruction of vertebral bodies. The CT scan showed that there were 12 cases of osteolytic bone destruction, 6 cases with unclear boundaries, remaining bone cortex and trabecular bone structure and 6 cases with mixed high and low-density shadow. MRI scan showed that T1WI sequence was low signal and the T2WI sequence was slightly higher or high signal. There were 6 cases of involved adnexa. The spinal cord or dura mater were compressed. There existed microbrain-like features in the cross section. The enhanced scan showed even enhancement to varying degrees. Conclusion CT and MRI can effectively reflect the range and shape of SPS lesions, and CT has obvious advantages in the reflection of remaining bone cortex and trabecular bone in tumors. The typical characteristic of MRI is microbrain-like bone destruction. A variety of imaging examinations ( mainly were CT and MRI) should be dopted to assist diagnosis according to the clinical manifestations of patients.