Objective To observe the follow-up results of 64 slice spiral CT angiography (CTA) before and after interventional therapy of type Ⅲ aortic dissection (AD) with covered stent. Methods 46 patients with type Ⅲ aortic dissection in our hospital from August 2007 to September 2012 were selected as the research objects. The selected patients were treated with dissection covered stent interventional therapy, and CTA was performed before and after operation. The diagnostic value of CTA in aortic dissection before operation and the feasibility of application in postoperative follow-up were analyzed. Results Before operation: 46 patients were canned by enhanced CT scan, diagnosed as aortic dissection, and true and false lumen were accurately distinguished. The images of break, quantity and intimal flap were clear and the involvement of vascular blood flow and blood supply of surrounding organs and tissues were visible. Stanford classification: 7 cases of type A, 39 cases of type B. The number of break was 52, including 40 cases of single break and 6 cases of double break. The involved arteries included brachiocephalic trunk, abdominal branch, internal iliac artery, iliac artery and left common carotid artery and a total of 48 branches were involved; After operation: With half year of follow-up, there was no death. 48 branches were involved, 13 involved branches were repaired and 29 cases were relieved. 6 cases of patients were with left renal atrophy. Conclusion 64 slice spiral CT can realize rapid diagnosis of AD and the accuracy is higher. Combined with post processing technology, the break and vascular distribution in patients with AD can clearly be observed, which can provide guidance for surgical treatment and can be used for postoperative long-term follow-up, noninvasive and convenient. It is of high clinical application value.