Head and Neck Imaging
Preparation of MR Contrast Agent of Vascular Endothelial Growth Factor Rectptor-targeted and its Experimental Study in MR Imaging in the Mice Model Implanted with Breast Cancer*
Author：LIU Min-ying
affiliation：Department of Medical Imaging, Nanfang Hospital Southern Medical University, Guangzhou 510515, Guangdong, China
PDFAbstract
Objective To prepare target Vascular Endothelial Growth Factor-Rectptor gadopentetate dimeglumine liposome and study in MR imaging in the Mice Model implanted with breast Cancer. Methods Anti-VEGF-Gd-DTPA liposome was prepared, and the physical and chemical properties were detected.The Breast cancer transplantated nude mice were divided into 2 groups (n=8). Anti-VEGF-Gd-DTPA liposome and Gd-DTPA were injected into the nude mice. After 30min, 2h, 4h, 8h, 24h, The tumor enhancement rate was calculated. Results The prepared Anti-VEGF-Gd-DTPA liposomes were characterized as nanoparticles. In vivo MRI, The group of Gd-DTPA resulted in a maximum tumor REV of 1.34±0.46 at 30min, The group of anti-VEGFGd-DTPA liposome resulted in a maximum tumor REV of 2.15±0.52 at 2h. In 2 groups of breast cancer, 2, 4, 8h，24h scan time points were compared, the difference was statistically significant (P＜0.05), the anti-VEGF-Gd-DTPA group was the highest REV. Conclusion VEGF antibody modified Gd-DTPA liposome can target the tumor vascular endothelial growth factor -receptor, which provides a new way of the tumor angiogenesis imaging diagnosis.
【Keyword】Vascular Endothelial Growth Factor ; Magnetic Resonance Imaging; Contrast Media
【Chart number】R445.2；R737.9
【Document Identification Number】A
【DOI】10.3969/j.issn.1672-5131.2015.12.001
Chinese journal of CT and MRI
th13Volume， th 12 Issue
2015Year12Month
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