Objective To explore the diagnostic value of CT and MRI in the clinical staging of endometrial carcinoma. Methods 63 cases of patients with endometrial carcinoma confirmed by surgery and histopathology in the hospital from January 2013 to December 2014 were selected as the research object and all of the patients received CT and MRI examination. The diagnostic accuracy of CT, MRI and CT combined with MRI was compared. Results The diagnostic accuracy of CT combined with MRI was the highest, reaching 87.3% which was higher than that of CT and MRI separate diagnosis and the comparison was statistically significant (P<0.05). The comparison of the accurate diagnosis rate of CT and MRI alone diagnosis was of no significant difference (P> 0.05). Conclusion Compared to CT and MRI alone diagnosis, CT combined with MRI is more conducive to make invasion degree of lesions to the surrounding organs clear and they can clearly show the size, the shape and the range of the lesions and access to more comprehensive information, which facilitates the staging confirmed diagnosis, then provide reference information for ensuring the scientificalness of the treatment programs, improve the prognosis of the patients, which is of greater clinical application and reference value.