Objective To study CT and MRI features of primary bone of the lymphoma. Methods Imaging of 19 PLB with pathologically confirmed were retrospectively reviewed. Results All lesions affected single bone, backbone 10, pelvis 6, femur 3. All bone lesions were infiltrative destruction with soft-tissue masses, CT scans displayed areas of different sizes of osteolytic cortical and marrow cavity destruction with large soft tissue masses or focus around the lesion. All of the lesions showed hypo-intense signal on T1WI and slightly hyperintense signal on T2WI. 1 soft-tissue lesion obviously uniform enhanced and 2 lesions slightly uniform enhanced after contrast-enhanced scans on CT; 12 lesion in bone obviously enhanced and 10 of 12 lesions with "lace-like sign", 3 lesions in bone slightly enhanced after contrast-enhanced scans on MRI; 9 lesions of soft-tissue masses obviously enhanced on MRI, only 2 lesion with necrosis, other 6 soft-tissue lesions slightly-moderate enhanced. Histological examination all identified B-cell lymphoma, 16 of them were diffuse larger B-cell lymphoma. Conclusion CT, MRI imaging of PBL has some characteristics, MRI has higher diagnostic value of PLB. associated with predilection site and age should be considered PBL possible.