Objective To summarize the MRI findings of patients with breast cancer and to analyze the correlation between findings and the expression of immunohistochemical CerbB-2 and Ki-67. Methods 62 cases of patients with breast cancer who were confirmed by surgery and pathology in our hospital between July 2013 and October 2015 were included in the study. All performed MRI examination.The specimens were fixed with formalin and after pathological diagnosis, immunohistochemical staining was performed. The positive rates of Ki67 and cerbB-2 were recorded. Results In 62 cases of patients with breast cancer, 57 cases were diagnosed by MRI and the diagnostic accuracy rate was 91.9%. 4 cases (6.5%) were misdiagnosed and 1 case (1.6%) was missed diagnosed. The MRI findings showed that there were mass shadows in 57 cases (46 masses were lumpy or lobulated, with fuzzy boundaries; 11cases were small nodular, with fuzzy boundaries). It showed isointense signal on T1WI and high signal on T2WI. After enhanced scan, lesions showed inhomogeneous enhancement. In 62 patients, MRI findings of 43 cases (69.4%) showed homogeneous ipsilateral axillary lymph node signal strength and 19 cases (30.6%) showed inhomogeneous ipsilateral axillary lymph node signal strength, suggesting there was lymph node metastasis. The shapes of lymph nodes were irregular in shape, with clear edges. Conclusion MRI findings of patients with breast cancer are characterized by mass shadow, fuzzy boundary, isointense signal on T1WI, high signal on T2WI and enhanced scan showinf inhomogeneous enhancement, which can be taken as the preferred examination means. Under the premise of MRI findings mentioned above, there exists positive expression of Ki67 or CerbB-2, doctors should be alert to lymph node metastasis and actively monitor the prognosis.