Objective To probe the diagnosing accuracy of DCE-MRI combined with DWI on endometrial carcinoma. Methods A total of 82 patients confirmed with endometrial carcinoma in this hospital from Jan 2014 to Apr 2016 were chosen. DCEMRI combined with DWI was adopted to diagnose the myometrial invasion and pathological stage of endometrial carcinoma. The sensitivity and specificity of diagnose were analyzed, and the consistency test between DCE-MRI combined with DWI and gold standard on pathological stage were conducted. Results The diagnosing accuracy of DCE-MRI combined with DWI on the myometrial invasion was 95.89% (70 cases), and the sensitivity, specificity, positive predictive value, and negative predictive value in shallow and deep myometrial invasion were all higher than 90%. The diagnosing accuracy on pathological stage was 91.46% (75 cases). There was strong consistency on diagnosing of pathological stage between DCE-MRI united to DWI and gold standard, with Kappa value being 0.88(P<0.05). Conclusion DCE-MRI combined with DWI has high diagnosing accuracy on myometrial invasion and preoperative pathological stage of endometrial carcinoma, and is expected to improve the diagnosing effect and prognosis of patients with endometrial carcinoma.