Objective To evaluate the correlation between IVIM and DCE-MRI parameters and immunohistochemical indices MVD, EGFR and Ki67. Methods From April 2013 to February 2015, 26 patients (13 males, 13 females; mean age 58 years, range 32-74 years) with pathologically confirmed non-small cell lung cancer were recruited. All patients underwent MR imaging. Axial single-shot respiratory triggered IVIM and breath holding 3D DCE-VIBE sequences were performed. Parameters of IVIM included ADCtotal and D value which reflected water molecule diffusion, and perfusion-related parameters D* and f values. Perfusion parameters of DCE-MRI were Ktrans, Kep, Ve and IAUC60. Spearman rank correlation coefficient was used to calculate the relationship between parameters from IVIM and DCE-MRI and immunohistochemical indices of MVD, EGFR and Ki67. Results Mean MVD of the 26 NSCLCs was (36.5±21.1), positive rate of EGFR was 54.3%, and the positive rate of Ki67 index was 86.4%. Moderate correlation was found between IAUC60 and MVD with r value of 0.687(P=0.000 <0.05), and weak correlation was found between Ktrans and MVD wtih r value of 0.444(P=0.005<0.05). No significant correlation between DCE parameters and EGFR or Ki67 was found. No significant correlation between IVIM parameters and all three immunohistochemical indices was found. Conclusion 1) DCE-MRI, as a non-invasive method, can be used to evaluate the microcirculation of lung cancer, 2) DCE-MRI and IVIM may not be applied to predict the results of EGFR and Ki67 of NSCLC.